Objective: To explore the application value of network interactive continuous care in improving self-management ability and quality of life in patients with gestational diabetes mellitus (GDM), and to provide reliable clinical evidence for continuous nursing application of gestational diabetes. Methods: A total of 172 primiparas with GDM who had voluntarily accepted the study were randomly assigned to the control group and the intervention group, 86 cases in each group. Control group received routine nursing care, intervention group received continuous network interactive nursing, which included establishing electronic health records, health education and psychological intervention, dietary intervention, moderate exercise intervention, monitoring blood glucose during pregnancy and postpartum, following up regularly after discharge. The level of self management and life quality were compared between two groups. Results: The score of life quality, the impact on jobs and the future, health self critiquing points in intervention group were higher than the control group at 42 days after delivery (P<0.05). The self management ability, exercise compliance, dietary compliance were also higher than the control group (P<0.05). Conclusion: Network interactive continuous care can effectively improve the self-management of patients with GDM, improve the life quality of them.