Objective: To explore the safety about the maternal and infant of twin pregnancy to vaginal delivery so as to provide reference about how to choose the delivery mode. Methods: 63 cases of vaginal birth for twin pregnancy were analyzed retrospectively. Results: The success rate was 87.3% (55/63). In the 55 successful cases, 9 multipara pregnancy and 46 primipara pregnancy; the number of cases for different gestational weeks in 28～33 +6 weeks, 34～36+6 weeks and ≥37 weeks were 39, 11and 5 respectively; The cases number of fetal position: head-head and head-breech were 32 and 23; the postpartum hemorrhage rate was 16.4% (9/55). Besides, there were 16 cases(1case≥34 weeks and 15 cases <34 weeks) with the neonatal asphyxia in the 110 newborns; the neonatal asphyxia rate was 14.5%; the neonatal asphyxia rates of the first newborns and the second newborns were 3.6%（2/55）and 25.5%（14/55）. The results showed that the cases of shorter gestational week had higher success rate of vaginal delivery, the neonatal asphyxia incidence in the gestational weeks< 34 weeks was higher than the gestational weeks≥34 weeks clearly (P<0.05), the incidence in the second newborns was higher (P<0.01). Conclusion: Twin pregnancy is not the contraindication to vaginal delivery, the mode of delivery can be determined by gestational weeks, delivery times and fetal position. We should make the personalized delivery plan. Finally the safety about the maternal and infant can be improved by closely monitor to the twin pregnancy women.