Objective: To explore the effect of nursing intervention based on information-motivation-behavioral skills model (IMB) on esophageal speech rehabilitation after total laryngectomy in patients with laryngeal cancer.Methods: A total of 112 patients who underwent total laryngectomy for laryngeal cancer were randomly divided into intervention group (56 cases) and control group (56 cases). The control group received routine care, and the intervention group provided rehabilitation nursing based on the information-motivation-behavioral skills model in addition to routine care. the efficacy of esophageal speech rehabilitation, the patient’s psychological status and the quality of life were compared between the two groups. Results: In the intervention group, 50 patients(89%) had successful esophageal pronunciation, and that was 38 (68%) in the control group, there were clinically significant differences between the two groups (P<0.01). There were no significant differences in psychological status scores and quality of life scores between the two groups before intervention (P>0.05). After the intervention, the SAS and SDS scores of the intervention group were significantly lower than the control group(P<0.01).The quality of life of the intervention group was significantly higher than that of the control group (P<0.05). Conclusion: The intervention focused on the information-motivation-behavioral skills model can improve the efficacy of esophageal speech training after total laryngectomy in patients with laryngeal cancer, promote the speech rehabilitation, reduce the anxiety and depression of patients, and improve the quality of life of patients.