Objective: To explore the effects of Baduanjin on relieving fatigue and improving sleep quality, so as to provide a theoretical basis for improving living quality of the hemodialysis patients. Methods: A total of 70 stable hemodialysis patients with fatigue were randomly divided into the control and the experimental group with 35 cases in each group. The control group received conventional treatment and nursing. The experimental group received the exercise of Baduanjin. Participants in this study were required to take this training for 3 months. Fatigue and sleep quality were analyzed before and after intervention in two groups. The revised Piper fatigue scale and the Pittsburgh sleep quality index were used to measure condition of fatigue and sleep. Results: There were statistically significant difference between two groups in the scores of total and each dimension for fatigue and sleep after intervention( P<0.05). Conclusion: Our study suggests the exercise of Baduanjin play a positive role in relieving fatigue and improving the quality of sleep among hemodialysis patients.