Objective: To discuss the effect of mixed teaching model based on rain classroom on clinical teaching of nursing students in orthopedics department. Methods: Totally 60 cases of nursing students in orthopedics department were divided into two groups. The students in the observation group were trained by the mixed teaching based on the rain class, while the control group was trained by the traditional teaching method and demonstration method. The teaching effect was contrasted. Results: The scores of students in the observation group were higher than that of the control group ( P<0.05). Conclusion: The mixed teaching model based on rain classroom can improve the scores of theory examination clinical practice examination of students and help to clinical teaching in orthopedics department.