Objective: To establish a quality evaluation index system for nursing care in neonatal non-invasive positive pressure ventilation in order to provide basis for nursing quality management. Methods: Based on the "structure-process-outcome" three-dimensional quality model, a comprehensive method, including literature review,semi-structured interviews, Delphi method, and analytic hierarchy process, was adopted to establish a quality indicator system for nursing in neonatal non-invasive positive pressure ventilation. Results: 2 rounds of expert consultations resulted in the effective response rates of 80% and 100%, with the authority coefficients of both 0.90, and the coordination coefficients of 0.367 and 0.357(P<0.001). The final evaluation index system for nursing quality in neonatal non-invasive positive pressure ventilation consisted of 3 first-level indicators, 12 second-level indicators, and 66 third-level indicators. Conclusion: The quality evaluation index system for nursing care in neonatal non-invasive positive pressure ventilation is scientific and reliable, which can provide science-based references for evaluating the clinical nursing quality in neonatal non-invasive positive pressure ventilation.