Objective: To explore the effect of multidisciplinary collaborative nursing model on self-perceived burden and quality of life of patients with recurrence of primary liver cancer after operation. Methods: 200 patients with postoperative recurrence of primary liver cancer were randomly divided into observation group and control group with 100 cases in each group. The control group was given routine nursing, and the observation group was given multidisciplinary collaborative nursing intervention on the basis of the control group. The scores of self-perceived burden scale and quality of life were compared between the two groups before and after nursing. Results: There was no significant difference in the scores of self-perceived burden scale, total score of quality of life and each dimension between the two groups before intervention( P>0.05). After the intervention, the scores of self-perceived burden scale, total score of quality of life and each dimension in the observation group were significantly higher than those in the control group （ P<0.05）. Conclusion: Multidisciplinary collaborative nursing model can not only reduce the self-perceived burden of patients with recurrence of primary liver cancer, but also improve the quality of life of patients.