Objective: To analyze the pregnancy outcome after reduction in multiple pregnancy and discuss the importance of nursing. Methods: Retrospective analysis was made on clinical data of 58 multiple pregnancy women who underwent fetal reduction from January 2016 to December 2018, including preoperative psychological care, postoperative diet and activity guidance, and pregnancy outcome. Results: All cases were reduced to single or twin. For reduction in first trimester vs in second trimester, the miscarriage within 2 weeks after surgery and the mean gestational age at delivery, had no significant difference( P>0.05), but the neonatal birth weights in second trimester were greater than in first trimester ( P<0.05); For fetal reduction by potassium chloride(KCl) vs by radiofrequency ablation（RAF）, the miscarriage within 2 weeks after surgery, gestational age and the survival rate were no statistically significant differences( P>0.05). Conclusion: Multiple pregnancy reduction can be performed in the first and second trimester, both KCl and RAF reductions can improve pregnancy outcomes. Preoperative psychological care and postoperative diet and activity guidance are beneficial to pregnancy outcome.