Objective: To explore the effect of home care on the self-management of patients with chronic heart failure (CHF) based on the theory of timing. Methods: 23 patients with first onset heart failure in cardiology from January to June 2018 in the observation group were given home care based on timing theory; 25 patients from January to December 2017 in control group were received routine care and follow-up. The level of self-management, quality of life and re-admission rate were recorded at 6 months after discharge. Results: The patients in observation group had higher level of self-management, lower scores of living quality, and lower re-admission rate than those of in the control group( P<0.05). Conclusion: Home care based on timing theory can effectively improve the self-management ability and quality of life, and reduce the rate of re-admission of CHF patients.