Objective: To explore the effect of full-cycle disease management model based on patient-centered on the self-care ability and complications of patients with multiple myeloma. Methods: A total of 104 patients with multiple myeloma from May 2018 to May 2019 were randomly divided into control group（ n=52）and intervention group（ n=52）.The control group received routine nursing method, and the intervention group adopted full-cycle management on the basis of routine nursing. Results: There was no statistically significant difference in the self-care behavior scores between the two groups before intervention（ P>0.05）.After the intervention, the scores of the self-care benhavior in the intervention group was higher than that in the control group（ P<0.05）, and the incidence of complications in the intervention group was lower than that in the control group, the diffenence was statistically significant（ P<0.05）. Conclusion: The application of the full-cycle management model can effectively improve the self-care ability and reduce the incidence of complications for patients with multiple myeloma.