Objective: To analyze the influencing factors of the success rate of blind insertion of naso-intestinal tube in critically ill patients. Methods: The critically ill patients who underwent blind insertion of naso-intestinal tube were selected. The patients’ acute physiology and chronic health evaluationⅡ(APACHEⅡ),sequential organ failure assessment(SOFA), Glasgow coma score(GCS), Ricker sedation and restlessness score(SAS), blood sugar, potassium, hospitalization time, bowel sounds, artificial airway, sedative and vasoactive drugs, operation, gastric motility drugs, mild hypothermia therapy, mechanical ventilation, and other general datum were collected. Logistic regression was used to analyze its influencing factors. Results: 156 critically ill patients with blind insertion of naso-intestinal tube were collected.132 were successfully inserted(84.6%),the average intubation time was 15.1±9.4. APACHEⅡ≥20,mechanical ventilation were risk factors for successful intubation.Bowel sounds was the protective factor for successful intubation. Conclusion: In addition to their own disease factors, drugs and therapeutic interventions may affect the intubation. Medical staff should evaluate as soon as possible and place the appropriate feeding tubes early.