Objective: To observe the application effect of WeChat on strengthening health education for children with asthma. Methods: A total of 124 children patients with asthma were selected and randomly divided into observation group and control group. Finally, 58 patients in the observation group and 53 in the control group completed the study. In the observation group, WeChat public account, group chat and short messaging service were added to strengthen the health education method based on the conventional health education of the control group. The control of asthma, the knowledge of asthma in parents, compliance of out-of-hospital treatment and asthma recurrence within 6 months of discharge were observed and compared between the two groups. Results: The control of asthma in the observation group was better( P=0.028), and parents had a higher degree of knowledge of pediatric asthma( P=0.009). After intervention, the compliance of children in observation group was higher than that of control group( P<0.001) and the proportion of recurrent asthma within 6 months was lower( P=0.05). Conclusion: The intensive education model based WeChat help to improve the effectiveness of asthma control in children, and improve the parental knowledge and treatment compliance of asthma parents.