关键词: 液体伤口敷料, 人表皮生长因子, 烧伤, 残余创面, 细菌生物膜, 联合

Abstract: Objective: The therapeutic efficacy of liquid wound dressing in conjunction with Human Epidermal Growth Factor Gel was examined for residual burn wound management, with particular emphasis on characterizing synergy and potential advantages over monotherapy. Methods: Using a convenience sampling method, patients with residual burn wounds who received dressing changes at the outpatient burn and plastic surgery department of a tertiary grade A hospital in Guilin, Guangxi Zhuang Autonomous Region from August 1, 2023, to August 1, 2024, were selected as study subjects. They were randomly divided into a control group and an observation group, with 40 cases in each group. The control group received wound disinfection and cleansing with 0.05% chlorhexidine acetate solution followed by topical application of recombinant Human Epidermal Growth Factor Gel. The observation group was treated with liquid wound dressing for moist wound cleansing, combined with topical application of Human Epidermal Growth Factor Gel. The Visual Analogue Scale (VAS) score during dressing changes, wound healing time, and wound healing rate were compared between the two groups. Results: The observation group demonstrated significantly lower VAS score and shorter residual wound healing time compared to the control group, with statistically significant differences (P<0.05). Furthermore, the observation group exhibited significantly higher residual wound healing rates at 1, 2, and 3 weeks post-treatment than the control group, and these differences were also statistically significant (P<0.05). Conclusion: The combined therapy of liquid wound dressing with Human Epidermal Growth Factor Gel represents an effective clinical strategy for reducing healing duration and promoting quality of life in residual burn wound management.

Key words: Liquid wound dressing, Human epidermal growth factor, Burns, Residual wounds, Bacterial biofilm, Combined