Objective: To analyze the effect of timely nursing intervention on skin problems, self-efficacy and quality of life of patients undergoing enterostomy. Methods: A total of 80 patients undergoing enterostomy were divided into the control group and the observation group with 40 patients in each group by the random number table method. The control group was given routine nursing while the observation group was additionally given timely nursing. The skin pain around the stoma at different time after surgery, self-efficacy before and after intervention, and the improvement of quality of life were evaluated with the visual analogue scale (VAS), self-efficacy scale for patients with stoma and quality of life scale (QOL) for patients with stoma. Results: The total incidence of skin problems around the stoma and related complications in the observation group was lower than that in the control group (P<0.05). VAS scores of the observation group were lower than those of the control group at 1 d, 3 d, 1 week and 2 weeks after surgery (P<0.05). After 3 months of intervention, scores of the self-efficacy scale and QOL in the observation group were higher than those in the control group(P<0.05). Conclusion: The application of timely nursing in the clinical intervention of patients undergoing enterostomy can reduce the incidence of stoma related skin problems, reduce postoperative pain, improve self-care ability, and improve the quality of life of patients.