Abstract: Objective: To explore the relationship between sleep quality, depression, and fatigue in patients with inflammatory bowel disease, and to provide reference for adopting targeted nursing measures to reduce patient fatigue. Methods: A survey was conducted among 340 patients with inflammatory bowel disease using a general information questionnaire, multidimensional fatigue index-20, hospital anxiety and depression scale, and Pittsburgh sleep quality index scale. The correlation analysis was carried out by SPSS 27.0 software. Model 4 in PROCESS macro program was used to analyze the mediating effect. Results: The fatigue scale score of patients with inflammatory bowel disease was 59.08±15.25, with a median of 5(2, 8) for depression and 6(4, 11) for sleep quality. The sleep quality of patients are positively correlated with depression and fatigue (P<0.05). Depression partially mediates the relationship between sleep quality and fatigue, with a mediation effect of 0.847 and a total effect of 1.814, accounting for 46.7% of the total effect. Conclusion: Sleep quality in patients with inflammatory bowel disease have a direct predictive effect on fatigue, while depression partially mediates the relationship between sleep quality and fatigue. Improving the sleep quality of patients and alleviating depression is an effective way to reduce their fatigue.

Key words: Inflammatory bowel disease, Sleep quality, Depression, Fatigue, Mediation effect

摘要： 目的：探讨炎症性肠病患者睡眠质量与抑郁、疲乏的关系，为采取针对性护理措施减轻患者的疲乏提供参考。方法：采用一般资料调查表、多维疲乏量表-20、医院焦虑抑郁量表、匹兹堡睡眠质量指数量表对340例炎症性肠病患者进行调查，应用SPSS 27.0进行统计分析，运用PROCESS宏程序中的Model 4进行中介效应分析。 结果：炎症性肠病患者疲乏量表得分为（59.08±15.25）分，抑郁量表得分为5（2，8）分，匹兹堡睡眠质量指数量表得分为6（4，11）分。患者的睡眠质量与抑郁、疲乏均呈正相关（P<0.05）。抑郁在睡眠质量与疲乏间起部分中介作用，中介效应为0.847，总效应为1.814，中介效应占总效应的46.7%。结论：炎症性肠病患者的睡眠质量对疲乏有直接预测作用，抑郁在睡眠质量与疲乏间起部分中介作用。改善患者的睡眠质量，缓解抑郁情绪是降低患者疲乏感的有效途径。

关键词: 炎症性肠病, 睡眠质量, 抑郁, 疲乏, 中介效应