Objective: To explore effect of assessment scale for acute pressure ulcer on operative patients with tumor. Methods: The surgical patients with tumor were put in the research in 2 years. Waterlow scale was used to assess patients of the control group (n=2215) in 2013, and the acute pressure ulcer assessment scale was adopted in the observation group (n=2458) in 2014. Then the incidence of acute pressure ulcer was compared between two groups. Results: The incidence of pressure ulcer in control group was 1.58%, it was 0.94% in observation group. There were statistically significant differences between the two groups (P<0.05). Conclusion: The items of acute pressure ulcer assessment scale in surgery closely relate to the character of operated patients. It provides the scientific and objective evidence for the nursing management in operating theater. Furthermore, it might help the clinical nurses to screen the patients with high risk, and reduce the incidence of acute pressure ulcer during operation.