Objective: To systematically evaluate the effects of experiential childbirth-simulation education on primipara.Methods: PubMed, Web of Science, Cochrane Library, CBM, CNKI and WanFang Data were used as the sources of literatures ，and all randomized controlled trials(RCTs) which studied the effects of experiential childbirth-simulation education on primipara were extracted from inception to July 10th, 2020. The meta-analysis was conducted using RevMan 5.3 software. Results: A total of 26 literatures involving 5 957 participants were included. The results of meta-analysis showed that experiential childbirth -simulation education could significantly increase the rate of natural delivery for primipara(OR=2.71, 95%CI: 2.40~3.05, P<0.01), decrease the incidence of postpartum hemorrhage(OR=0.11, 95%CI: 0.04~0.33, P<0.01) and neonatal asphyxia (OR=0.23, 95%CI: 0.12~0.44, P<0.01), meanwhile improve the anxiety (SMD=-1.68, 95%CI: -2.01~-1.35, P<0.01), depression(SMD=-1.37, 95%CI: -1.58~-1.15, P<0.01), and self-efficacy(MD= 5.60, 95%CI:2.92~8.28, P<0.01) of primipara. Conclusion: Experiential childbirth-simulation education is efficacious in increasing the rate of natural delivery for primipara, decreasing the incidence of postpartum hemorrhage and neonatal asphyxia, and improving the anxiety, depression and self-efficacy of primipara. Because of the limitation of quality of included studies, more high-quality studies are needed to confirm the above conclusion.