Objective: To systematically evaluate the risk factors of implantable venous access port related thrombosis in tumor patients by meta -analysis. Methods: PubMed, Cochrane Library,Web of Science, Embase, CBM, CNKI, WanFang Data and VIP database were retrieved from the inception to April 1st，2021. Two researchers independently screened the literature and extracted the data. The RevMan 5.3 software was used for meta-analysis. Results: A total of 17 literatures with 25 risk factors were included. Meta-analysis of results showed that risk factors of implantable venous access port-related thrombosis in tumor patients including age≥60(OR=0.30, 95% CI 0.13～0.70) ,BMI≥24 kg/m² (OR=0.60, 95% CI 0.47～0.76), infection (OR=6.34, 95% CI 1.38～29.11) ,thrombosis history(OR=3.41, 95% CI 1.63～7.14), tumor stage III ~ IV (OR=0.47, 95% CI 0.26～0.85), gastrointestinal carcinoma of tumor classification(OR=0.68, 95% CI 0.56～0.83), TEC(OR= 4.13, 95% CI 1.38～12.34)，surgical history(OR=1.43, 95%CI 1.06～1.92)，and port tip location(OR=0.15, 95%CI 0.07～0.32).Conclusion: The results of this study showed that age, BMI, infection, history of thrombosis, tumor stage, tumor classification, chemotherapy regimen, surgical history, and port tip location were the risk factors of implantable venous access portrelated thrombosis. Medical staffs should increase the management of risk factors in clinical nursing of implantable venous access port to prevent thrombosis.