关键词: 淋巴瘤, 症状群, 生活质量, 纵向研究, 相关性研究

Abstract: Objective: To investigate symptom clusters and quality of life in lymphoma patients at different time points during chemotherapy, and to explore the dynamic changes in the correlation between symptom clusters and quality of life. Methods: A total of 159 patients with lymphoma who received initial chemotherapy were selected conveniently. The symptoms and quality of life of the patients were investigated before chemotherapy (T1), after the third cycle (T2) and after the sixth cycle (T3). Results: Before chemotherapy, patients had gastrointestinal symptom clusters, psychological symptom clusters and lymphoma B symptom clusters. After the third and sixth cycles of chemotherapy, lymphoma B symptom clusters disappeared, and chemotherapy-related symptom clusters increased. Among quality of life, the physical function, role function and cognitive function of patients in 3 cycles were compared, and the differences were significantly different (P<0.01). Symptom groups were negatively correlated in each dimension of quality of life before chemotherapy and after the sixth cycle of chemotherapy (P<0.05). Chemotherapy-related symptom group and psychological symptom group were negatively correlated in all dimensions of quality of life after the third cycle of chemotherapy (P<0.05). Conclusion: There are multiple stable symptom clusters in lymphoma patients during chemotherapy, which are negatively correlated with quality of life. Clinicians should manage the symptoms of lymphoma patients during chemotherapy, reduce the burden of symptoms and improve the quality of life.

Key words: Lymphoma, Symptom cluster, Quality of life, Longitudinal study, Correlation study