关键词: 肿瘤, 免疫检查点抑制剂, 生活质量, 影响因素

Abstract: Objective: To investigate the status of quality of life and its influencing factors in cancer patients receiving immune checkpoint inhibitors(ICIs) therapy, and to provide basis for improving the quality of life of the patients. Methods: A total of 216 patients receiving ICIs therapy from September 2021 to February 2022 were included，the general information questionnaire, ECOG score，European organization for research and treatment of cancer quality of life questionnaire-core 30 and the symptom assessment scale were used in the investigation. Results: The lowest general health score of patients treated with ICIs therapy was 66.67(50.00, 83.33). The multiple linear regression analysis showed that treatment method, symptom burden and ECOG score were the influencing factors of body function and role function (Adj R² =0.485, 0.383). Meanwhile, age, gender, symptom burden and ECOG score were the influencing factors of emotional function (Adj R²= 0.350), and age, symptom burden and ECOG score were the influencing factors of cognitive function(Adj R² =0.250). While, symptom burden and ECOG score were the influencing factors of social function and general health (Adj R² =0.201, 0.314). Conclusion: The general health status of patients treated with ICIs therapy is not well. We should pay attention to the patients who are young , female, receiving combined treatment, with high ECOG score and severe symptom burden, and implement effective nursing strategies to improve the quality of life in cancer patients.

Key words: Cancer, Immune checkpoint inhibitors, Quality of life, Influencing factor