关键词: 化疗所致周围神经病变, 非药物管理, 证据总结

Abstract: Objective: To search, evaluate and summarize the best evidence on prevention and non -pharmacological management of chemotherapy-induced peripheral neuropathy (CIPN), and to provide reference for clinical practice and standard setting. Methods: A systematic search of domestic and foreign databases, computer decision systems, guidelines and websites of professional academic organizations on the interventions of prevention and non-pharmacological for CIPN, including clinical decision-making, evidence summary, guidelines, expert consensus and systematic review. The literature retrieval period of database was from inception to December 31, 2022. The literature was independently evaluated, extracted and integrated by 2 researchers. Results: A total of 34 articles were included, involving 1 clinical decision-making, 3 guidelines, 5 expert consensus and 25 systematic reviews. Finally, 27 pieces of best evidence in 7 aspects (including risk identification, physical therapy, chemotherapy medication adjustment, rehabilitation exercise, health education, diet guidance and life guidance) were formed. Conclusion: This study summarized the best evidence for prevention and non-pharmacological interventions of CIPN, and provided an evidence-based basis for clinical staff. It is suggested that medical staff should rationally apply and constantly update the evidence on the basis of comprehensive consideration of the actual situation.

Key words: Chemotherapy-induced peripheral neuropathy, Non-pharmacological interventions, Evidence summary