关键词: 肾移植, 衰弱, 发生率, Meta 分析

Abstract: Objective: To systematically evaluate the prevalence of frailty among renal transplant recipients and provide evidence-based support for early identification and intervention. Methods: Computerized searches were conducted in CNKI, VIP, Wanfang, PubMed, Web of Science, Embase, and Cochrane Library for survey studies on the frailty status of renal transplant patients. The search period spanned from the inception of each database to December 16, 2024. Two researchers independently performed literature screening, data extraction, and quality assessment. Meta-analysis was conducted using Stata 15.1. Results: A total of 19 studies were included, with an aggregate sample size of 8 841 cases. The meta-analysis revealed that the prevalence of frailty among renal transplant recipients was 20%. Subgroup analysis showed that the prevalence of frailty before renal transplantation was 17.7%, while it was 21.3% after transplantation; the prevalence was 19.1% when measured using the PFP tool, and 22.3% with other measurement tools; the prevalence was 18.9% in male recipients, and 23.6% in female recipients; the prevalence was 16.9% in the U.S., and 24.1% in other countries; the prevalence was 17.8% in studies conducted from 2012 to 2019, and 21.8% in those from 2020 to 2024; the prevalence was 18.6% in cohort studies, and 24.0% in cross-sectional studies. Conclusion: The prevalence of frailty among renal transplant recipients is relatively high, underscoring the importance of early screening and intervention.

Key words: Renal transplantation, Frailty, Incidence rate, Meta-analysis