Abstract: Objective: To retrieve and integrate the best evidence on the management of neurogenic bowel dysfunction (NBD) in patients with spinal cord injury (SCI), so as to provide a reference for healthcare professionals. Methods: Search for evidence on the management of NBD in patients with spinal cord injury from databases including UpToDate, BMJ Best Practice, JBI, Cochrane Library, International Guideline Collaboration, National Guideline Clearinghouse, American Spinal Injury Association, PubMed, Embase, Web of Science, CNKI, and Wanfang Database. This includes clinical decisions, clinical practice guidelines, evidence summary, systematic reviews, expert consensus, and randomized controlled trials, from the inception of the databases up to April 15, 2022. The quality of the literature will be assessed by two researchers. Results: A total of 18 articles were included, and 22 pieces of evidence were summarized from 6 aspects, including bowel function assessment, nutritional support, non-pharmacological interventions, pharmacological interventions, rehabilitation exercises and educational support. Conclusion: This study summarizes the best evidence for the prevention and management of NBD in patients with spinal cord injury. Healthcare professionals should combine the clinical context and patients′ willingness to make clinical application.