Abstract: Objective: To search, evaluate and summarize the best evidence on prevention and non -pharmacological management of chemotherapy-induced peripheral neuropathy (CIPN), and to provide reference for clinical practice and standard setting. Methods: A systematic search of domestic and foreign databases, computer decision systems, guidelines and websites of professional academic organizations on the interventions of prevention and non-pharmacological for CIPN, including clinical decision-making, evidence summary, guidelines, expert consensus and systematic review. The literature retrieval period of database was from inception to December 31, 2022. The literature was independently evaluated, extracted and integrated by 2 researchers. Results: A total of 34 articles were included, involving 1 clinical decision-making, 3 guidelines, 5 expert consensus and 25 systematic reviews. Finally, 27 pieces of best evidence in 7 aspects (including risk identification, physical therapy, chemotherapy medication adjustment, rehabilitation exercise, health education, diet guidance and life guidance) were formed. Conclusion: This study summarized the best evidence for prevention and non-pharmacological interventions of CIPN, and provided an evidence-based basis for clinical staff. It is suggested that medical staff should rationally apply and constantly update the evidence on the basis of comprehensive consideration of the actual situation.

Key words: Chemotherapy-induced peripheral neuropathy, Non-pharmacological interventions, Evidence summary

摘要： 目的：检索、评价并总结有关化疗致周围神经病变预防及非药物管理的最佳证据，为临床实践与标准的制定提供参考。方法： 系统检索国内外数据库、计算机决策系统、指南及专业学术组织网站中关于化疗致周围神经病变预防及非药物管理的临床决策、证据总结、指南、专家共识及系统评价。检索时限为建库至 2022 年 12 月 31 日。由 2 名研究者独立对纳入文献进行质量评价、资料提取及整合。结果：共纳入 34 篇文献，其中临床决策 1 篇、指南 3 篇、专家共识 5 篇、系统评价 25 篇，从风险识别、物理治疗、化疗用药调整、康复锻炼、健康教育、饮食指导和生活指导 7 个方面，共总结 27 条证据。结论：该研究总结了化疗致周围神经病变预防及非药物管理的最佳证据，可为临床提供循证依据，建议在综合考虑实际情况的基础上，医护人员合理应用并不断更新证据。

关键词: 化疗所致周围神经病变, 非药物管理, 证据总结