Objective: To observe the clinical effect of look-ahead epidural catheterization for farrowing interval puerperae with preeclampsia. Methods: 60 cases of single birth and head-position primiparas in preeclampsia who were willing to accept the labor anesthesia were divided into observation group and control group. (30 cases in each group). The primiparas of control group was performed to labor anesthesia with epidural catheterization in active phase when cervix was up to 3cm, while it was performed after labor and administration when pain was felt in observation group. The vital signs, labor time, pain occurrence, delivery outcome and perinatal fetus outcome were recorded in different time points in 2 groups. Results: The score of VAS on various points in time during the incubation period of first stage in observation group was obviously lower, and the difference was statistically significant (P<0.001); There was no significant difference in the first and second labor time between two groups (P>0.05).The arterial pressure in observation was lower than control group at all time (P<0.05).But both two groups showed that the delivery outcome had no obvious difference.（P>0.05）. There was no significant difference in the outcome of parturition in observation group (P＞0.05). in addition, the disease of the eclampsia didn't occur among these two groups.Conclusion: It is efficacious that relief throe via labor analgesia with look-ahead of epidural catheterization, so as to maintain the patient’s circulatory stability, prevent the disease of the eclampsia during labor without affecting the outcome of delivery. This therapy can protect the safety of mother and infant.