Objective: To perform a re-evaluation of the systematic review on efficacy and safety of heparin for pediatric central venous catheter maintenance. Methods: A literature search of Cochrane Library, EMBASE, Pubmed from their inception to January 2017.Hand searching of articles on systematic review and Meta analysis related to efficacy and safety of heparin for pediatric central venous catheter maintenance. Use AMSTAR tools to evaluate the methodology quality of the included studies and assess the quality of outcome indicators by the GRADE system. Results: 7 articles on systematic review and Meta analysis were included. 6 articles met the criteria of high quality and 1 medium based on AMSTAR evaluation. GRADE evaluation showed that there were 3 high, 1 medium and 3 low level articles on the evidence cluster quality of 7 outcome indicators. Conclusion: Heparin may be effective in maintaining patency of venous catheters in children, but the quality of evidence needs to be further improved.