Objective: To study the influence of enteral nutrition combined with parenteral nutrition on nutritional condition of patients after laparoscopic repair of huge peptic ulcer perforation. Methods: A total of 80 cases were enrolled and divided randomly into control and observation groups (each of 40 cases). The patients in control group received parenteral nutrition, while the patients in observation group adoped enteral nutrition combined with parenteral nutrition. Then we compared differences of nutrition index including serum albumin, prealbumin and transferrin levels after 3d, 5d and 7d, immunological index including IgG quantitation, CD3+, CD4+, and CD4+/CD8+ percentages, inflammatory index including white blood cell count, IL-6, C reactive protein and procalcitonin levels, the clinical indicators including mean time of exhaust and defecate, rates of fecal occult blood and incision infection. Results: The levels of serum albumin, prealbumin and transferrin in the two groups after 3d, 5d and 7d were gradually increasing, what’s more, those were all significantly higher in observation group(P＜0.05).They were the same as immunological index, while the contrary to inflammatory index. The mean time of exhaust and defecate in observation group was significantly shorten, and rates of fecal occult blood and incision infection were both lower(P＜0.05). Conclusion: It can greatly improve status of nutrition and immune in laparoscopic repair of huge peptic ulcer perforation, and reduce inflammatory response, which can bring better clinical and nursing values.