Objective: To understand the clinical nursing students’ current situation of professional sense of benefit and self-efficacy, and analyze the relationship between them, so as to provide advice to improve the level of the clinical nursing students’ professional sense of benefits. Methods: A total of 487 clinical nursing students in three level grade comprehensive hospitals were investigated with general self-efficacy scale and nursing professional sense of benefit scale. Results: The score of the clinical nursing students’ professional sense of benefit was（3.86±0.63）, and the score of general self-efficacy was （27.79±4.85）. The professional sense of benefit and its various dimensions were positivity correlated with self-efficacy (r=0.305~0.571，P＜0.05). Conclusion: The clinical nursing students’ professional sense of benefit and self-efficacy were placed a better than the middle level. Nursing educators can improve the level of the clinical nursing students’ professional sense of benefit by improving the professional identity, creating a good relationship between nurses and patients.