Objective: To investigate the cognition status and needs for PICC care in clinic nurses of care of venous access (CVA). Methods: A convenience sampling was employed to select 114 nurses working in CVA clinic of 25 hospitals in Tianjin; a self-made questionnaire was created to investigate the participants’ cognition on PICC care. The questionnaires were provided on the spot and taken back right after they were finished. The data collected from the participants were calculated. Results: The survey results showed that the highest level of recognition was rules and regulations in the management system (67.26%), the lowest was staffing requirement (23.90%); in the self-evaluation of PICC nursing ability, effective communication ability (3.50±0.520) was the highest, scientific research ability(2.36±0.846) was the lowest; only 56.7% of the patients thought that the implementation of the cluster bundle for PICC was very good. The results of univariate analysis showed that there were statistically significant difference in whether management by head nurse or not, PICC training or not, educational level (P<0.05). The correlation factor analysis showed that the cognitive level of nurses was positively correlated with age, working years and PICC working years. Conclusion: We should to improve in the aspects of health education for patient, training system of nurse, and a complete set of device and instrument, in order to ensure the safety of intravenous treatment.