关键词: 患儿, 青少年, 肝移植, 依从性, 系统评价

Abstract: Objective: To systematically review the influencing factors and intervention measures of medication compliance among children undergoing liver transplantation. Methods: Cochrane Library, Medline, Embase, CINAHL, CNKI, WanFang Data, CBM and VIP were retrieved from inception to February 2021. Two researchers independently conducted literature screening, data extraction and quality evaluation, and then systematic review was conducted. Results: A total of 19 studies were included, covering 7 cohort studies, 4 case-control studies, 4 cross-sectional studies and 4 quasi-experiment studies. The rate of medication noncompliance among children undergoing liver transplantation ranged from 5.6% to 59.7%. Medication adherence was affected by age, family, socioeconomic factors, mental and psychological factors, etc. Cross-age peer mentoring program and transition readiness skills, etc. can improve medication adherence. Conclusion: Elder in age, transition period from adolescence to adulthood, parents’ low education level, single-parent family, and history of abuse were influencing factors of medication compliance in children undergoing liver transplantation. Identification of compliance influencing factors and exploration of targeted intervention strategies are necessary to improve medication compliance.

Key words: Children, Adolescent, Liver transplantation, Medication compliance, Systematic review