关键词: 复发难治性淋巴瘤, CAR-T 细胞疗法, 临床试验, 真实体验, 质性研究

Abstract: Objective: To understand the real experience of patients with relapsed and refractory lymphoma receiving chimeric antigen receptor T(CAR-T) cell therapy, and to provide references and suggestions for taking targeted nursing intervention. Methods: The descriptive phenomenological design was adopted in the study. Thirteen patients with relapsed and refractory lymphoma who received CAR-T clinical trials in the lymphoma ward of a gade A tertiary cancer hospital in Tianjin from January 2，2023 to February 1，2024 were interviewed by semi-structured methods. The data was analyzed, summarized and induced by Colaizzi 7-step analysis method. Results: The real experience of thirteen patients with relapsed and refractory lymphoma receiving CAR-T clinical trial can be summarized into three themes, including perceived trial benefits and risks (remission or disappearance of discomfort symptoms related to lymphoma, short-term symptoms related to CAR-T cell therapy, and long-term symptoms after CAR-T cell therapy), multiple complex psychological experiences (self-contradiction and conflict running through the whole process, traumatic stress disorder and post-traumatic growth coexisting, showing diversified expectations for treatment), and actively seeking diversified support (paying attention to treatment -related information, longing for continuity of professional medical services, and hoping to obtain family support). Conclusion: Patients with relapsed and refractory lymphoma have many experiences in CAR-T cell therapy. Medical staff should formulate targeted nursing strategies according to patients′ specific conditions to help them recover as soon as possible and return to normal life.

Key words: Relapsed and refractory lymphoma, CAR-T cell therapy, Clinical trial, Real experience, Qualitative research