关键词: 运动干预, 癌症, 肌少症, Meta 分析

Abstract: Objective: To evaluate the effects of exercise intervention on muscle mass, muscle strength and physical function in patients with tumor-related sarcopenia patients using meta analysis. Methods: Randomized controlled trials on the effectiveness of exercise intervention on patients with tumor-related sarcopenia were retrieved from electronic databases of CNKI, Wanfang data, CBM, PubMed, Cochrane Library, CINAHL, Ovid Discovery, etc. RevMan 5.3 software was used to perform meta-analysis. Results: Eight studies were included, with 489 patients. Meta analysis results show that，exercise intervention can improve muscle mass of tumor-related sarcopenia(Skeletal Muscle Mass Index) [SMD=0.96, 95% CI(0.68, 1.23), P<0.05], muscle mass (lean mass weight) [SMD=0.64，95% CI(0.35, 0.94), P<0.05]; muscle strength (upper limb) [MD=4.66, 95% CI(2.51, 6.81), P<0.05], muscle strength(leg strength) [SMD=1.05，95% CI(0.64, 1.46), P<0.05]; Body performance (step rate)[MD=0.50, 95% CI(0.42, 0.58), P<0.05]. Conclusion: Exercise intervention can effectively improve muscle strength, muscle mass and physical function in patients with tumor-related sarcopenia. Due to the diversity of cancer types, inconsistent outcome measurement standards, and differences in the definition of outcome indicators, the research results have high heterogeneity. So, high quality and multi-center RCT researches are needed to explore effective interventions for the treatment of tumor-related sarcopenia and to improve the homogeneity of research results.

Key words: Exercise, Tumor, Sarcopenia, Meta analysis