关键词: 艾滋病, 肾脏替代治疗, 死亡, 危险因素, Meta分析

Abstract: Objective: To evaluate the risk factors associated with death in patients with AIDS receiving renal replacement therapy by meta-analysis system. Methods: Cochrane Library, PubMed, Web of Science, Embase, Wanfang, CNKI, and VIP were searched for the risk factors associated with death in patients with AIDS combined with renal replacement therapy from the inception to May 13, 2023, and meta-analysis was performed by using RevMan 5.3. Results: A total of 9 papers containing 25 relevant risk factors were included. Among them, advanced age [HR=1.21, 95%CI (1.12, 1.32)] was a risk factor for death in patients with AIDS receiving renal replacement therapy (P＜0.001). Lack of highly active antiretroviral therapy (HAART) [HR=0.47, 95%CI (0.32, 0.69)], prolonged hospitalization [HR=0.94, 95%CI (0.90, 0.98)], normal body mass index (BMI) (18.5 kg/m² ≤ BMI <24 kg/m²) [HR=0.34, 95%CI (0.17, 0.68)], overweight and obesity (BMI ≥24 kg/m²) [HR=0.41, 95%CI(0.23, 0.72)] were protective factors for death in patients with AIDS receiving renal replacement therapy (P＜0.001). Conclusion: Advanced age is a risk factor for death in patients with AIDS receiving renal replacement therapy, and lack of HAART, prolonged hospitalisation, normal BMI, overweight and obesity are protective factors. The targeted intervention measures should be taken to reduce the prevelence of death.

Key words: AIDS, Renal replacement therapy, Death, Risk factors, Meta-analysis