Objective: To systematically review the effect of clinical nursing pathway (CNP) in patients with knee replacement arthroplasty. Methods: Databases including PubMed、EMbase、The Cochrane Library、EBSCO、CNKI、Wanfang and VIP Data were electronically searched. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using RevMan 5.3 software. Results：A total of 14 RCTs involving 1123 patients. The results of meta-analysis showed that: CNP compared with the control group, the knee function score and the achievement rate of knowledge were increased, the incidence of postoperative complications was decreased, the time of hospitalization was decreased and the patients’ nursing satisfaction was increased.Conclusion: CNP can improve the knee function score and the achievement rate of knowledge, reduce the incidence of postoperative complications and the time of hospitalization, as well as it can improve the patients’ nursing satisfaction. Due to the limited quality and quantity of the included studies, the above conclusions need more high quality studies to verify.