Objective: To establish a scientific and standardized quality-sensitive index system for central sterial supply department（CSSD）, so as to provide a basis for objective evaluation and improvement of the work quality of CSSD. Methods:A total of 15 experts from the management of CSSD, nursing management and hospital infection management in tertiary hospitals were interviewed by Delphi method for two rounds, and the evaluation indexes were screened. The weight of the indexes was determined by AHP, and the quality-sensitive index system for CSSD was established. Results: The effective recovery rates of two rounds of expert consultation were 100%, meanwhile, the authority coefficients were 0.867 and 0.880, respectively. The coefficients of variation of the third level items were 0.000~0.167. The construction of the quality-sensitive index system for CSSD contained three first level indicators, 20 second level indicators, and 51 third level indicators.Conclusion: The quality-sensitive index system for CSSD constructed in this study highlights the characteristics of the disinfection and supply specialty, and puts forward specific, objective and quantifiable quality evaluation standards for the disinfection and supply management. The quality-sensitive index system can be used for the quality evaluation of the disinfection and supply specialty.