关键词: 乳腺癌, 经济毒性, 生存质量

Abstract: Objective: To explore the current status of financial toxicity in patients with breast cancer and its impact on quality of life. Methods: The general information questionnaire, the Comprehensive Score for Financial Toxicity based on the Patient-Report Outcome Measures (COST-PROM), and the Functional Assessment of Cancer Therapy-Breast (FACT-B) were used to investigate 210 patients with breast cancer hospitalized in the department of breast oncology in a Class A tertiary hospital in Tianjin. Results: Patients with breast cancer scored 18.00 (12.00, 23.00) points in financial toxicity and (77.99±22.65) points in quality of life. 65.7% of patients had financial toxicity. Spearman correlation analysis showed that the total score of financial toxicity was positively correlated with the total score of quality of life (r=0.567, P<0.01). Multiple linear regression analysis showed that chemotherapy and financial toxicity were the influencing factors of quality of life and explained 43.3% of the overall variation. Conclusion: The financial toxicity in patients with breast cancer is common. Chemotherapy and financial toxicity can significantly predict patients′ quality of life. Nurses can implement targeted measures to reduce chemotherapy-related adverse reactions and reduce the level of financial toxicity, thereby improving patients′ quality of life.

Key words: Breast cancer, Financial toxicity, Quality of life