关键词: 新辅助治疗, 临床试验, 乳腺癌, 真实体验

Abstract: Objective: To understand the real experience of breast cancer patients participating in the clinical trial of neoadjuvant therapy, so as to provide basis for personalized nursing of breast cancer patients participating in the clinical trial of neoadjuvant therapy. Methods: Thirteen breast cancer patients who participated in the clinical trial of neoadjuvant therapy from July to October 2022 were selected as the research subjects by objective sampling, and semi-structured interviews were conducted. Results: Three themes were extracted including significant differences in cognition of clinical trials (blind questioning and resistance, excessive dependence and expectation, scientific treatment and understanding), heavy or relieved psychological experience (confusion and fear, inferiority and shame, gratitude and happiness，adaptation and growth), and seeking for science popularization and support (desire for treatment knowledge, expectation of medical care and peer support). Conclusion: Breast cancer patients who participated in the clinical trial of neoadjuvant therapy lacked professional science popularization approach and support, and their real experience was affected by cognition, with significant differences in feelings. Clinical nurses should assess the needs of breast cancer patients who participate in the clinical trial of neoadjuvant therapy, conduct personalized education to correct cognitive bias and assist in correct decision-making. Clinical staffs should give humanistic care to decrease negative emotions, and cooperate with medical care, family and social support forces to allow patients to grow after trauma.

Key words: Neoadjuvant therapy, Clinical trial, Breast cancer, Real experience